Which cell death modality wins the contest for photodynamic therapy of cancer?
N. I. Lobachevsky State University of Nizhny Novgorod · Sechenov University · +2 more institutions
Abstract
Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed for the treatment of several types of cancer. Traditionally, cell death induced by PDT was categorized into three types: apoptosis, cell death associated with autophagy, and necrosis. However, with the discovery of several other regulated cell death modalities in recent years, it has become clear that this is a rather simple understanding of the mechanisms of action of PDT. New observations revealed that cancer cells exposed to PDT can pass through various non-conventional cell death pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, and…
Citation impact
- FWCI
- 18.87
- Percentile
- 100%
- References
- 242
Authors
5- TATatiana A. Mishchenko
N. I. Lobachevsky State University of Nizhny Novgorod
- IVIrina V. Balalaeva
N. I. Lobachevsky State University of Nizhny Novgorod
- AAAnastasia A. Gorokhova
N. I. Lobachevsky State University of Nizhny Novgorod
- MVMaria V. Vedunova
N. I. Lobachevsky State University of Nizhny Novgorod
- DVDmitri V. KryskoCorresponding
Sechenov University, Ghent University, Cancer Research Institute Ghent, N. I. Lobachevsky State University of Nizhny Novgorod
Topics & keywords
- Necroptosis
- Pyroptosis
- Programmed cell death
- Photodynamic therapy
- Immunogenic cell death
- Autophagy
- Mitotic catastrophe
- Cancer
- Good health and well-being