Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

Abstract Insufficient tumor accumulation and distribution of photosensitizers as well as low antitumor immunity severely restrict the therapeutic efficacy of photothermal therapy (PTT). Cancer-associated fibroblasts (CAFs) play a key role in tumor extracellular matrix (ECM) remodeling and immune evasion. Reshaping tumor microenvironment via CAF regulation might provide a potential approach for complete tumor elimination in combination with PTT. Here, tumor cell-derived microparticles co-delivering calcipotriol and Indocyanine green (Cal/ICG@MPs) are developed to modulate CAFs for improved PTT efficacy. Cal/ICG@MPs efficiently target tumor tissues and regulate CAFs to reduce tumor ECM, resulting in enhanced…

• NN
  National Natural Science Foundation of China

  Awards: 81627901, 82073796 and 81627901, 82073796, 2020YFA0710700, 81974459, 2018YFA0208900
• CP
  China Postdoctoral Science Foundation
• NK
  National Key Research and Development Program of China

  Awards: 81627901, 2020YFA0710700, 2018YFA0208900