A guide to the organ-on-a-chip

Leung, Chak Ming; Haan, Pim de; Ronaldson-Bouchard, Kacey; Kim, Ge-Ah; Ko, Jihoon; Rho, Hoon Suk; Chen, Zhu; Habibović, Pamela; Jeon, Noo Li; Takayama, Shuichi; Shuler, Michael L.; Vunjak‐Novakovic, Gordana; Frey, Olivier; Verpoorte, Elisabeth; Toh, Yi‐Chin

doi:10.1038/s43586-022-00118-6

articleNature Reviews Methods PrimersMay 12, 2022HYBRID OA

A guide to the organ-on-a-chip

CMChak Ming Leung PDPim de Haan KRKacey Ronaldson-Bouchard GKGe-Ah Kim JKJihoon Ko

National University of Singapore · University of Groningen · +8 more institutions

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Abstract

Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. To better mimic human physiology, the chips are designed to control cell microenvironments and maintain tissue-specific functions. Combining advances in tissue engineering and microfabrication, OoCs have gained interest as a next-generation experimental platform to investigate human pathophysiology and the effect of therapeutics in the body. There are as many examples of OoCs as there are applications, making it difficult for new researchers to understand what makes one OoC more suited to an application than another. This Primer is intended to give an introduction to the aspects of OoC that…

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Topics & keywords

Topics

Keywords

Computer science
Organ-on-a-chip
Microfabrication
Microfluidics
Biochemical engineering
Data science
Nanotechnology
Engineering

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