Factors influencing the blood-brain barrier permeability
Zhejiang Chinese Medical University
Abstract
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful blood-borne, endogenous and exogenous substances and maintains the homeostatic microenvironment. All constituent cell types play indispensable roles in the BBB's integrity, and other structural BBB components, such as tight junction proteins, adherens junctions, and junctional proteins, can control the barrier permeability. Regarding the need to exchange nutrients and toxic materials, solute carriers, ATP-binding case families, and ion transporter, as well as transcytosis regulate the influx and efflux transport, while the difference in localisation and expression can contribute to functional differences in transport…
Citation impact
- FWCI
- 19.38
- Percentile
- 100%
- References
- 226
Authors
6Topics & keywords
- Blood–brain barrier
- Adherens junction
- Transcytosis
- Tight junction
- Cell biology
- Permeability (electromagnetism)
- Transporter
- Chemistry