Evaluation of synergism in drug combinations and reference models for future orientations in oncology

Current cancer therapy includes a variety of strategies that can comprise only one type of treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for cancer therapy, though sometimes associated with undesired side effects and the development of drug resistance. For this reason, drug combination is an approach that has been proposed to overcome the problems related to monotherapy and several studies have already demonstrated the superiority of combined therapies compared to monotherapy. The main goal when designing and evaluating drug combinations is to achieve synergistic effects by demonstrating that the combined effects are greatly superior to the expected from the…

• PO
  Programa Operacional Temático Factores de Competitividade
• FP
  Fundação para a Ciência e a Tecnologia

  Award: IF/00092/2014/CP1255/CT0004
• ER
  European Regional Development Fund