Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis

The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae – a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to…

• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Awards: 2019/, 2021/, 2019/23566-6
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico

  Award: 400099/2022-5
• V
  Vetenskapsrådet

  Award: 2021-06050