Micro‐Gel Ensembles for Accelerated Healing of Chronic Wound via pH Regulation

Abstract The pH value in the wound milieu plays a key role in cellular processes and cell cycle processes involved in the process of wound healing. Here, a microfluidic assembly technique is employed to fabricate micro‐gel ensembles that can precisely tune the pH value of wound surface and accelerate wound healing. The micro‐gel ensembles consist of poly (hydroxypropyl acrylate‐ co ‐acrylic acid)‐magnesium ions (poly‐(HPA‐ co ‐AA)‐Mg 2+ ) gel and carboxymethyl chitosan (CMCS) gel, which can release and absorb hydrogen ion (H + ) separately at different stages of healing in response to the evolution of wound microenvironment. By regulating the wound pH to affect the proliferation and migration of cell on the…

• NN
  National Natural Science Foundation of China

  Awards: 21908103, 81870396, 21978132, 21736006
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions