reviewBMC MedicineMay 23, 2022GOLD OA

Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis

BZBaoqi ZengLGLe GaoQZQingxin ZhouKYKai YuFSFeng Sun

Fifth Tianjin Central Hospital · University of Hong Kong · +2 more institutions

PubMed
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Abstract

Abstract Background It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive overview of the effectiveness profile of COVID-19 vaccines against VOC. Methods Published randomized controlled trials (RCTs), cohort studies, and case-control studies that evaluated the VE against VOC (Alpha, Beta, Gamma, Delta, or Omicron) were searched until 4 March 2022. Pooled estimates and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. VE was defined as (1-estimate). Results Eleven RCTs (161,388 participants), 20 cohort studies (52,782,321…

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291
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Authors

5

Topics & keywords

Topics
Keywords
  • Medicine
  • Meta-analysis
  • Coronavirus disease 2019 (COVID-19)
  • Vaccination
  • Randomized controlled trial
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Confidence interval
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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