Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases

Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular…

• NN
  National Natural Science Foundation of China

  Awards: 81970287, 82100292, 82070436
• NS
  Natural Science Foundation of Hubei Province

  Awards: 81970287, 2020CFB234