Human organoids in basic research and clinical applications

Tang, Xiao-Yan; Wu, Shanshan; Wang, Da; Chu, Chu; Hong, Yuan; Tao, Mengdan; Hu, Hao; Xu, Min; Guo, Xing; Liu, Yan

doi:10.1038/s41392-022-01024-9

reviewSignal Transduction and Targeted TherapyMay 24, 2022GOLD OA

Human organoids in basic research and clinical applications

XTXiao-Yan TangSWShanshan Wu DWDa Wang CCChu Chu YHYuan Hong

Target (United States) · Institute for Stem Cell Biology and Regenerative Medicine · +3 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy individuals or patients that recapitulate the cellular heterogeneity, structure, and functions of human organs. The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens, maintenance and differentiation resemble primary tissues, enhancing the potential to study both human physiology and developmental stage. As they are similar to their original organs and carry human genetic information, organoids derived from patient hold great promise for biomedical research and…

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Authors

10

XT
Xiao-Yan Tang
Target (United States), Institute for Stem Cell Biology and Regenerative Medicine, Ministry of Education, State Key Laboratory of Reproductive Medicine, Nanjing Medical University
SW
Shanshan Wu
Target (United States), Institute for Stem Cell Biology and Regenerative Medicine, Ministry of Education, State Key Laboratory of Reproductive Medicine, Nanjing Medical University
DW
Da Wang
Target (United States), Institute for Stem Cell Biology and Regenerative Medicine, Ministry of Education, State Key Laboratory of Reproductive Medicine, Nanjing Medical University
CC
Chu Chu
Target (United States), Institute for Stem Cell Biology and Regenerative Medicine, Ministry of Education, State Key Laboratory of Reproductive Medicine, Nanjing Medical University
YH
Yuan Hong
Target (United States), Institute for Stem Cell Biology and Regenerative Medicine, Ministry of Education, State Key Laboratory of Reproductive Medicine, Nanjing Medical University

Topics & keywords

Topics

Keywords

Organoid
Induced pluripotent stem cell
Stem cell
Regenerative medicine
Biology
Transplantation
Cellular differentiation
Computational biology

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