Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine
Université Fédérale de Toulouse Midi-Pyrénées · Institut de Pharmacologie et de Biologie Structurale · +2 more institutions
Abstract
Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer. IL-33 is abundant in the nuclei of tissue-derived cells, including endothelial cells from blood vessels, epithelial cells from barrier tissues, and fibroblastic stromal cells from various tissues. IL-33 is released upon cell damage or tissue injury and activates Myd88-dependent signaling pathways in cells expressing the ST2 (IL-1RL1) receptor. Analysis of patient samples and studies in murine models support an important role of IL-33/ST2 signaling in allergic inflammation in different tissues (lung,…
Citation impact
- FWCI
- 22.32
- Percentile
- 100%
- References
- 128
Authors
2Topics & keywords
- Innate lymphoid cell
- Interleukin 33
- Immunology
- Thymic stromal lymphopoietin
- Biology
- Allergic inflammation
- Inflammation
- Cytokine
- Good health and well-being