Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy
Zhengzhou University · First Affiliated Hospital of Zhengzhou University · +1 more institution
Abstract
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In diabetic microvasculature, the intracellular hyperglycemia causes damages to the vascular endothelium, via multiple pathophysiological process consist of inflammation, endothelial cell crosstalk with podocytes/pericytes and exosomes. In addition, DN and DR diseases development are involved in several critical regulators including the cell adhesion molecules (CAMs), the vascular endothelial growth factor (VEGF) family and the Notch signal. The present review attempts to gain a deeper understanding of the pathogenesis…
Citation impact
- FWCI
- 46.35
- Percentile
- 100%
- References
- 271
Authors
2- JYJing Yang
Zhengzhou University, First Affiliated Hospital of Zhengzhou University, Henan Provincial Center for Disease Control and Prevention
- ZLZhangsuo LiuCorresponding
Zhengzhou University, First Affiliated Hospital of Zhengzhou University, Henan Provincial Center for Disease Control and Prevention
Topics & keywords
- Endothelial dysfunction
- Diabetic retinopathy
- Pathogenesis
- Medicine
- Retinopathy
- Diabetes mellitus
- Endothelium
- Diabetic nephropathy
- Good health and well-being