reviewJournal of Controlled ReleaseJun 7, 2022HYBRID OA

Dissolving microneedles: Applications and growing therapeutic potential

University College Cork

PubMed
Indexed incrossrefpubmed

Abstract

Microneedles are a rapidly developing method for the transdermal delivery of therapeutic compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function by penetrating the stratum corneum layer of the skin producing a microchannel through which therapeutic agents may be delivered. To date, coated and hollow microneedles have been the most successful, despite suffering from issues such as poor drug loading capabilities and blocked pores. Dissolving microneedles, on the other hand, have superior drug loading as well as other positive attributes that make it an ideal delivery system, including simple methods of fabrication and disposal, and abundantly available materials. Indeed,…

Citation impact

449
total citations
FWCI
31.33
Percentile
100%
References
126
Citations per year

Authors

3

Topics & keywords

Keywords
  • Transdermal
  • Nanotechnology
  • Drug delivery
  • Materials science
  • Stratum corneum
  • Biomedical engineering
  • Medicine
  • Pharmacology
UN Sustainable Development Goals
  • Good health and well-being
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Funding