Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency
Sichuan University · State Key Laboratory of Biotherapy · +3 more institutions
Abstract
Tumor immunotherapy is only effective in a fraction of patients due to a low response rate and severe side effects, and these challenges of immunotherapy in clinics can be addressed through induction of immunogenic cell death (ICD). ICD is elicited from many antitumor therapies to release danger associated molecular patterns (DAMPs) and tumor-associated antigens to facilitate maturation of dendritic cells (DCs) and infiltration of cytotoxic T lymphocytes (CTLs). The process can reverse the tumor immunosuppressive microenvironment to improve the sensitivity of immunotherapy. Nanostructure-based drug delivery systems (NDDSs) are explored to induce ICD by incorporating therapeutic molecules for chemotherapy,…
Citation impact
- FWCI
- 48.86
- Percentile
- 100%
- References
- 307
Authors
9- ZLZhilin Li
Sichuan University, State Key Laboratory of Biotherapy
- XLXiaoqin Lai
Sichuan University, State Key Laboratory of Biotherapy
- SFShiqin Fu
Sichuan University, State Key Laboratory of Biotherapy
- LRLong Ren
Sichuan University, State Key Laboratory of Biotherapy
- HCHao Cai
Sichuan University, State Key Laboratory of Biotherapy
Topics & keywords
- Immunotherapy
- Tumor microenvironment
- Medicine
- Immunogenic cell death
- Cancer research
- Immune system
- Photothermal therapy
- Cancer immunotherapy
- Good health and well-being