Immune Senescence, Immunosenescence and Aging

With aging, there is increased dysfunction of both innate and adaptive immune responses, which contributes to impaired immune responses to pathogens and greater mortality and morbidity. This age-related immune dysfunction is defined in general as immunosenescence and includes an increase in the number of memory T cells, loss of ability to respond to antigen and a lingering level of low-grade inflammation. However, certain features of immunosenescence are similar to cellular senescence, which is defined as the irreversible loss of proliferation in response to damage and stress. Importantly, senescence cells can develop an inflammatory senescence-associated secretory phenotype (SASP), that also drives…

• MJ
  Michael J. Fox Foundation for Parkinson's Research

  Award: ASAP-000592
• NI
  National Institutes of Health

  Awards: AG062413, U19 AG056278, U54 AG076041, AG063543, R01 AG069819, AG056278, AG043376, RO1 AG063543, P01 AG043376, ASAP-000592, P01 AG062413, AG069819, R01 AG063543
• NI
  National Institute on Aging