Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum
Centre for Human Genetics · University of Oxford · +8 more institutions
Abstract
The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa's Gauteng region uncovered two new sublineages, BA.4 and BA.5, which are taking over locally, driving a new wave. BA.4 and BA.5 contain identical spike sequences, and although closely related to BA.2, they contain further mutations in the receptor-binding domain of their spikes. Here, we study the neutralization of BA.4/5 using a range of vaccine and naturally immune serum and panels of monoclonal antibodies. BA.4/5 shows reduced…
Citation impact
- FWCI
- 75.20
- Percentile
- 100%
- References
- 59
Authors
47- ATAekkachai Tuekprakhon
Centre for Human Genetics, University of Oxford
- RNRungtiwa Nutalai
Centre for Human Genetics, University of Oxford
- ADAiste Dijokaite-Guraliuc
Centre for Human Genetics, University of Oxford
- DZDaming Zhou
Centre for Human Genetics, University of Oxford
- HMHelen M. Ginn
Diamond Light Source
Topics & keywords
- Biology
- Virology
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Antibody
- Coronavirus disease 2019 (COVID-19)
- 2019-20 coronavirus outbreak
- Betacoronavirus
- Immunology
- Good health and well-being