Signaling pathways of chronic kidney diseases, implications for therapeutics

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) deposition. Lipotoxicity and oxidative stress are the driving force for the loss of nephron including tubules, glomerulus, and endothelium. NLRP3 inflammasome signaling, MAPK signaling, PI3K/Akt signaling, and RAAS signaling involves in lipotoxicity. The upregulated Nox expression and the decreased Nrf2 expression result in oxidative stress directly. The injured renal resident cells release proinflammatory cytokines and chemokines to recruit immune cells such as macrophages from bone marrow. NF-κB signaling, NLRP3 inflammasome…

• NN
  National Natural Science Foundation of China

  Awards: 81974097, 81873602, 2018YFC1314000, 82100729, 81770711, 2017QYTD20, 81974096, 81961138007
• CP
  China Postdoctoral Science Foundation
• NK
  National Key Research and Development Program of China

  Awards: 81873602, 81961138007, 81770711, 2017QYTD20, 81974096, 2018YFC1314000