articleNatureJun 1, 2022HYBRID OA

The longitudinal dynamics and natural history of clonal haematopoiesis

MAMargarete A. FabreJGJosé Guilherme de AlmeidaEFEdoardo FiorilloEMEmily MitchellADAristi Damaskou

Wellcome/MRC Cambridge Stem Cell Institute · University of Cambridge · +6 more institutions

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Abstract

Abstract Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis 1–4 . The understanding of how and when clonal haematopoiesis develops, the factors that govern its behaviour, how it interacts with ageing and how these variables relate to malignant progression remains limited 5,6 . Here we track 697 clonal haematopoiesis clones from 385 individuals 55 years of age or older over a median of 13 years. We find that 92.4% of clones expanded at a stable exponential rate over the study period, with different mutations driving substantially different growth rates, ranging from 5% ( DNMT3A…

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Topics & keywords

Topics
Keywords
  • Biology
  • Haematopoiesis
  • Somatic cell
  • Somatic evolution in cancer
  • Genetics
  • Context (archaeology)
  • Mutation
  • Gene
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