reviewFrontiers in Cardiovascular MedicineJun 1, 2022GOLD OA

Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis

HJHui JiangYZYongwen ZhouSMSeyed Mohammad NabaviASAmirhossein SahebkarPJPeter J. Little

University of Science and Technology of China · Chinese Academy of Sciences · +5 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Atherosclerosis is an immuno-metabolic disease involving chronic inflammation, oxidative stress, epigenetics, and metabolic dysfunction. There is compelling evidence suggesting numerous modifications including the change of the size, density, and biochemical properties in the low-density lipoprotein (LDL) within the vascular wall. These modifications of LDL, in addition to LDL transcytosis and retention, contribute to the initiation, development and clinical consequences of atherosclerosis. Among different atherogenic modifications of LDL, oxidation represents a primary modification. A series of pathophysiological changes caused by oxidized LDL (oxLDL) enhance the formation of foam cells and atherosclerotic…

Citation impact

283
total citations
FWCI
19.34
Percentile
100%
References
87
Citations per year

Authors

8

Topics & keywords

Topics
Keywords
  • Foam cell
  • Endothelial dysfunction
  • Oxidative stress
  • Inflammation
  • Lipoprotein
  • Endothelium
  • Low-density lipoprotein
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding