Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease

Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) abnormalities. Multiple studies have shown that many of the brain's immunological cells, specifically microglia and astrocytes, are involved in AD pathogenesis. Cells of the innate immune system play an essential role in eliminating pathogens but also regulate brain homeostasis and AD. When activated, innate immune cells can cause programmed cell death through multiple pathways, including pyroptosis, apoptosis, necroptosis, and PANoptosis. The cell death often results in the release of proinflammatory cytokines that propagate the innate…

• AL
  American Lebanese Syrian Associated Charities

  Awards: AI124346, AR056296, AI101935
• NI
  National Institutes of Health

  Awards: AR056296, CA253095, AI101935, AI124346, AI160179