Noninvasive proteomic biomarkers for alcohol-related liver disease
University of Copenhagen · Novo Nordisk Foundation · +8 more institutions
Abstract
Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet understanding of the three key pathological features of the disease-fibrosis, inflammation and steatosis-remains incomplete. Here, we present a paired liver-plasma proteomics approach to infer molecular pathophysiology and to explore the diagnostic and prognostic capability of plasma proteomics in 596 individuals (137 controls and 459 individuals with ALD), 360 of whom had biopsy-based histological assessment. We analyzed all plasma samples and 79 liver biopsies using a mass spectrometry (MS)-based proteomics workflow with short gradient times and an enhanced, data-independent acquisition scheme in only 3 weeks of…
Citation impact
- FWCI
- 44.98
- Percentile
- 100%
- References
- 68
Authors
16- LNLili NiuCorresponding
University of Copenhagen, Novo Nordisk Foundation, Max Planck Institute of Biochemistry
- MTMaja Thiele
University of Southern Denmark, Odense University Hospital
- PEPhilipp E. Geyer
CS Diagnostics, Max Planck Institute of Biochemistry
- DNDitlev Nytoft Rasmussen
Odense University Hospital
- HWHenry Webel
University of Copenhagen, Novo Nordisk Foundation
Topics & keywords
- Medicine
- Disease
- Liver disease
- Alcoholic liver disease
- Computational biology
- Bioinformatics
- Internal medicine
- Biology
- Good health and well-being