Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity
Indexed incrossrefpubmed
Abstract
Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as compared to natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity from natural resources, especially daily food, implies a promising direction for exploring treatment strategies for human diseases. Here, we report a CQDs-based biocompatible nanozyme prepared from chlorogenic acid (ChA), a major bioactive natural product from coffee. We found that ChA CQDs exhibited obvious GSH oxidase-like activities and subsequently promoted cancer cell ferroptosis by perturbation of GPX4-catalyzed lipid repair systems. In vivo, ChA CQDs dramatically suppressed the tumor growth in HepG2-tumor-bearing mice with negligible…
Citation impact
274
total citations
- FWCI
- 18.31
- Percentile
- 100%
- References
- 54
Citations per year
Authors
9Topics & keywords
Topics
Keywords
- Immune system
- Cancer cell
- Chemistry
- Toxicity
- Natural product
- Nanomedicine
- Cancer research
- Biocompatible material
UN Sustainable Development Goals
- Responsible consumption and production
No related works found for this paper.