Scale-up polymeric-based nanoparticles drug delivery systems: Development and challenges

The development of nanotechnology as a crucial technology in recent years has resulted in new and creative nanomedicine applications. The characteristics of nanomedicine are determined by size, surface, drug loading, targeting potential and combination with diagnostic agents for therapeutic applications to form nano multifunctional devices. Nanomedicine provides a new healthcare paradigm and is capable of revitalizing existing clinical products. Polymeric nanoparticles (PNPs) are promising nanomedicines. With increasing demands for medical, pharmaceutical, or nutritional applications, nanoparticles (NPs) require high reproducibility, homogeneity, and control over their properties; upscaling processes are…