articleNational Science ReviewJun 3, 2022GOLD OA

A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

ZCZhi ChenJLJingfeng LiTLTianzhong LiTFTaojian FanCMChangle Meng

Shenzhen University · Shenzhen Inno Translational Medicine Institute · +10 more institutions

PubMed
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Abstract

The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-CoV-2 variants, including Omicron, are required to be identified as soon as the samples are identified as 'positive'. Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time, we have developed MOPCS (Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance (SPR) with the 'gene scissors' clustered regularly…

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499
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100%
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Authors

23

Topics & keywords

Topics
Keywords
  • CRISPR
  • Computational biology
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Coronavirus disease 2019 (COVID-19)
  • Surface plasmon resonance
  • Biology
  • Virology
  • Gene
UN Sustainable Development Goals
  • Good health and well-being
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