Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

The present review details a chronological description of the events that took place during the development of mesoporous materials, their different synthetic routes and their use as drug delivery systems. The outstanding textural properties of these materials quickly inspired their translation to the nanoscale dimension leading to mesoporous silica nanoparticles (MSNs). The different aspects of introducing pharmaceutical agents into the pores of these nanocarriers, together with their possible biodistribution and clearance routes, would be described here. The development of smart nanocarriers that are able to release a high local concentration of the therapeutic cargo on-demand after the application of…

• DF
  Deutsche Forschungsgemeinschaft
• M
  Max-Planck-Gesellschaft
• MD
  Ministerio de Ciencia e Innovación

  Award: PID2019-106436RB-I00
• HE
  H2020 European Research Council

  Award: Advanced Grant. ERC-2015-AdG Proposal No. 694160