articleCellMay 31, 2022BRONZE OA

Glioma progression is shaped by genetic evolution and microenvironment interactions

FSFrederick S. VarnKCKevin C. JohnsonJMJan MartinekJTJason T. HuseMPMacLean P. Nasrallah

Jackson Laboratory · The University of Texas MD Anderson Cancer Center · +33 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type…

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485
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79.60
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100%
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Authors

147

Topics & keywords

Topics
Keywords
  • Biology
  • Glioma
  • Tumor microenvironment
  • Evolutionary biology
  • Genetics
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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