Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice

Abstract Background Neuronal pyroptosis and neuroinflammation with excess microglial activation are widely involved in the early pathological process of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive neuromodulatory technique, has recently been reported to be anti-inflammatory and regulate microglial function. However, few studies have elucidated the role and mechanism of rTMS underlying regulating neuronal pyroptosis and microglial polarization. Methods We evaluated the motor function in middle cerebral artery occlusion/reperfusion (MCAO/r) injury mice after 1-week intermittent theta-burst rTMS (iTBS) treatment in the early phase with or without depletion of microglia…

• NN
  National Natural Science Foundation of China

  Awards: 31900719, 81972140, 82172544, 81972141, 2018SHZDZX01
• FU
  Fudan University

  Award: 2018SHZDZX01
• SA
  Science and Technology Commission of Shanghai Municipality

  Award: 2018SHZDZX01
• NK
  National Key Research and Development Program of China

  Award: 2019YFA0709504