Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as a promising approach to cancer immunotherapy. However, biocompatible strategies to activate pyroptosis remain rare. Here, we show that a photocatalytic superoxide radical (O2–•) generator, NI-TA, triggers pyroptosis in cancer cells. NI-TA was designed to take advantage of an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed that the pyroptosis triggered by NI-TA under conditions of photoexcitation proceeds through a caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). NI-TA was found to function…

• WF
  Welch Foundation

  Award: F-0018
• NR
  National Research Foundation of Korea

  Awards: 2020H1D3A1A02080172, 2019M3E5D1A01068998
• CS
  China Scholarship Council

  Award: 2021907030009