Anterior insula as a gatekeeper of executive control
Canadian Institutes of Health Research · University of California, Los Angeles · +1 more institution
Abstract
Executive control is a complex high-level cognitive function that relies on distributed brain circuitry. We propose that the anterior insular cortex plays an under-appreciated role in executive processes, acting as a gatekeeper to other brain regions and networks by virtue of primacy of action and effective connectivity. The flexible functional profile of the anterior insular subdivision renders it a key hub within the broader midcingulo-insular 'salience network', allowing it to orchestrate and drive activity of other major functional brain networks including the medial frontoparietal 'default mode network' and lateral frontoparietal 'central executive network'. The microanatomy and large-scale connectivity…
Citation impact
- FWCI
- 31.47
- Percentile
- 100%
- References
- 223
Authors
2Topics & keywords
- Insular cortex
- Default mode network
- Salience (neuroscience)
- Insula
- Neuroscience
- Psychology
- Cognition
- Executive functions