Biosynthetic potential of the global ocean microbiome

Abstract Natural microbial communities are phylogenetically and metabolically diverse. In addition to underexplored organismal groups 1 , this diversity encompasses a rich discovery potential for ecologically and biotechnologically relevant enzymes and biochemical compounds 2,3 . However, studying this diversity to identify genomic pathways for the synthesis of such compounds 4 and assigning them to their respective hosts remains challenging. The biosynthetic potential of microorganisms in the open ocean remains largely uncharted owing to limitations in the analysis of genome-resolved data at the global scale. Here we investigated the diversity and novelty of biosynthetic gene clusters in the ocean by…

• NS
  National Science Foundation

  Awards: 51NF40_180575, 1829831
• GA
  Gordon and Betty Moore Foundation

  Awards: https://doi.org/10.37807/GBMF9204, GBMF9204, 10.37807/GBMF9204, doi.org/10.37807/GBMF9204
• OF
  Ocean Foundation
• FT
  Fondation Tara Océan
• EC
  European Commission

  Awards: 835067, 897571, 101000392
• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFB 1371, 395357507
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Awards: 205320_185077, 407540_167331, 37807, 51NF40_180575, 205321_184955
• ET
  Eidgenössische Technische Hochschule Zürich

  Awards: ETH-21 18-2, 20-1 FEL-07
• MD
  Ministerio de Economía y Competitividad
• HH
  Helmut Horten Stiftung
• PU
  Peter und Traudl Engelhorn Stiftung