Genetically Modified Porcine-to-Human Cardiac Xenotransplantation
University of Maryland, Baltimore · United Therapeutics (United States) · +1 more institution
Abstract
A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically modified pig source animal that had 10 individual gene edits. Immunosuppression was based on CD40 blockade. The patient was weaned from ECMO, and the xenograft functioned normally without apparent rejection. Sudden diastolic thickening and failure of the xenograft occurred on day 49 after transplantation, and life support was withdrawn on day 60. On autopsy, the xenograft was found to be edematous, having nearly doubled in weight. Histologic examination revealed…
Citation impact
- FWCI
- 130.44
- Percentile
- 100%
- References
- 21
Authors
13- BPBartley P. GriffithCorresponding
University of Maryland, Baltimore
- CECorbin E. Goerlich
University of Maryland, Baltimore
- AKAvneesh K. Singh
University of Maryland, Baltimore
- MRMartine Rothblatt
University of Maryland, Baltimore, United Therapeutics (United States)
- CLChristine L. Lau
University of Maryland, Baltimore
Topics & keywords
- Xenotransplantation
- Medicine
- Extracorporeal membrane oxygenation
- Immunosuppression
- Transplantation
- Autopsy
- Cardiomyopathy
- Heart transplantation