Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to loss of cognitive abilities and ultimately, death. With no cure available, limited treatments mostly focus on symptom management. Identifying early changes in the disease course may provide new therapeutic targets to halt or reverse disease progression. Clinical studies have shown that cortical and hippocampal hyperactivity are a feature shared by patients in the early stages of disease, progressing to hypoactivity during later stages of neurodegeneration. The exact mechanisms causing neuronal excitability changes are not fully characterized; however, animal and cell models have provided insights into some of the factors…

• RL
  Rebecca L. Cooper Medical Research Foundation

  Awards: #PG2020645, #F2021971
• UO
  University of Wollongong
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council

  Awards: APP1105445, APP1135720