Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
Daffodil International University · BGC Trust University Bangladesh · +13 more institutions
Abstract
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including…
Citation impact
- FWCI
- 50.02
- Percentile
- 100%
- References
- 500
Authors
16- TBTalha Bin Emran
Daffodil International University, BGC Trust University Bangladesh
- ASAsif Shahriar
The University of Texas Rio Grande Valley
- ARAar Rafi Mahmud
Mawlana Bhashani Science and Technology University
- TRTanjilur Rahman
University of Chittagong
- MHMehedy Hasan Abir
Chattogram Veterinary and Animal Sciences University
Topics & keywords
- Multiple drug resistance
- Drug resistance
- Cancer
- Medicine
- Epigenetics
- Efflux
- Autophagy
- Drug
- Good health and well-being