Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Sun Yat-sen University · Eighth Affiliated Hospital of Sun Yat-sen University · +2 more institutions
Abstract
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and association analyses and candidate gene approaches illustrate the multigenic complexity of cardiovascular disease. Several epigenetic mechanisms, such as DNA methylation, histone modification, and noncoding RNA, which are of importance for cardiovascular disease development and regression. Targeting epigenetic key enzymes, especially the DNA methyltransferases, histone methyltransferases, histone acetylases, histone deacetylases and their regulated target genes, could represent an attractive new route for the diagnosis and treatment of cardiovascular diseases. Herein, we summarize the knowledge on epigenetic history and…
Citation impact
- FWCI
- 27.11
- Percentile
- 100%
- References
- 319
Authors
7- YSYuncong ShiCorresponding
Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University
- HZHuanji Zhang
Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University
- SHSuli Huang
Shenzhen Center for Disease Control and Prevention
- LYLi Yin
Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University
- FWFeng Wang
Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University
Topics & keywords
- Epigenetics
- Histone
- Biology
- Methyltransferase
- DNA methylation
- Disease
- Genetics
- Epigenomics
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAwards: FTWS2019003, 82061160372, JCYJ20180306174648342, 20201062, 82073408, 81870506, JCYJ20190808102005602
- SMShenzhen Municipal Science and Technology Innovation Council
- NKNational Key Research and Development Program of ChinaAward: 2020YFC2004405
- BABasic and Applied Basic Research Foundation of Guangdong Province