Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine
The University of Melbourne · Peter Doherty Institute · +4 more institutions
Abstract
Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) mRNA vaccines for SARS-CoV-2 contain small amounts of PEG, but it is not known whether PEG antibodies are enhanced by vaccination and what their impact is on particle-immune cell interactions in human blood. We studied plasma from 130 adults receiving either the BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) mRNA vaccines or no SARS-CoV-2 vaccine for PEG-specific antibodies. Anti-PEG IgG was commonly detected prior to vaccination and was significantly boosted a mean of 13.1-fold (range 1.0-70.9) following mRNA-1273 vaccination and a mean of 1.78-fold (range 0.68-16.6) following…
Citation impact
- FWCI
- 28.53
- Percentile
- 100%
- References
- 41
Authors
22- YJYi JuCorresponding
The University of Melbourne, Peter Doherty Institute, RMIT University
- WSWen Shi Lee
The University of Melbourne, Peter Doherty Institute
- EHEmily H. Pilkington
The University of Melbourne, Peter Doherty Institute, Monash University
- HGHannah G. Kelly
The University of Melbourne, Peter Doherty Institute
- SLShiyao Li
The University of Melbourne
Topics & keywords
- Vaccination
- Reactogenicity
- Antibody
- Medicine
- PEG ratio
- Immunology
- Virology
- Immune system
- Good health and well-being