MicroRNA-Based Diagnosis and Therapy
Ho Chi Minh City Open University · University of East Anglia
Abstract
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene expression. Alteration in miRNA expression results in changes in the profile of genes involving a range of biological processes, contributing to numerous human disorders. With high stability in human fluids, miRNAs in the circulation are considered as promising biomarkers for diagnosis, as well as prognosis of disease. In addition, the translation of miRNA-based therapy from a research setting to clinical application has huge potential. The aim of the current review is to: (i) discuss how miRNAs traffic intracellularly and extracellularly; (ii) emphasize the role of circulating miRNAs as attractive potential biomarkers for…
Citation impact
- FWCI
- 51.42
- Percentile
- 100%
- References
- 135
Authors
3Topics & keywords
- microRNA
- Computational biology
- Bioinformatics
- Translation (biology)
- Disease
- Gene expression
- Biology
- Medicine
- Good health and well-being