articleNature CommunicationsJun 27, 2022GOLD OA

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

BWBartosz WiernickiSMSophia MaschalidiJJJonathan J. PinneySASandy AdjemianTVTom Vanden Berghe

Ghent University · Cancer Research Institute Ghent · +5 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell death that is characterized by iron accumulation and lipid peroxidation, has not yet been fully evaluated from this perspective. Here we present an inducible model of ferroptosis, distinguishing three phases in the process-'initial' associated with lipid peroxidation, 'intermediate' correlated with ATP release and 'terminal' recognized by HMGB1 release and loss of plasma membrane integrity-that serves as tool to study immune cell responses to ferroptotic cancer cells. Co-culturing ferroptotic cancer cells with dendritic cells…

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356
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Authors

7

Topics & keywords

Topics
Keywords
  • Cancer cell
  • Immunogenic cell death
  • Immune system
  • Programmed cell death
  • Necroptosis
  • Immunogenicity
  • Cancer research
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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