Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

Hossain, Md. Sanower; Kader, Md. Abdul; Goh, Khang Wen; Islam, Md. Maidul; Khan, Md. Sharif; Rashid, Md. Harun-Ar; Ooi, Der Jiun; Coutinho, Henrique Douglas Melo; Al‐Worafi, Yaser Mohammed; Moshawih, Said; Lim, Ya Chee; Kibria, K. M. Kaderi; Ming, Long Chiau

doi:10.3389/fphar.2022.865801

reviewFrontiers in PharmacologyJun 30, 2022GOLD OA

Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

MSMd. Sanower Hossain MAMd. Abdul Kader KWKhang Wen Goh MMMd. Maidul Islam MSMd. Sharif Khan

International Islamic University Malaysia · Mawlana Bhashani Science and Technology University · +7 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and spices used in cooking, practised for generations, have been shown to contain CRC protective effect or even be useful as an anti-CRC adjuvant therapy when used in high doses. Herbs and spices contain many bioactive compounds and possess many beneficial health effects. The chemopreventive properties of these herbs and spices are mainly mediated by the BCL-2, K-ras, and MMP pathways, caspase activation, the extrinsic apoptotic pathway, and the regulation of ER-stress-induced apoptosis. As a safer natural alternative, these herbs and…

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343

total citations

FWCI: 60.59
Percentile: 100%
References: 208

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Authors

13

Topics & keywords

Topics

Keywords

Traditional medicine
Medicine
Herb
Colorectal cancer
Chemoprotective
Curcuma
Pharmacology
Cancer

UN Sustainable Development Goals

Good health and well-being

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Funding

GM
Guangzhou Medical University