Mitochondrial dysfunction in cell senescence and aging

Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential, typically accompanied by increased production of oxygen free radicals, is a cause and a consequence of cellular senescence and figures prominently in multiple feedback loops that induce and maintain the senescent phenotype. Here, we summarize pathways that cause mitochondrial dysfunction in senescence and aging and discuss the major consequences of mitochondrial dysfunction and how these consequences contribute to senescence and aging. We also…

• GF
  Glenn Foundation for Medical Research
• TN
  Ted Nash Long Life Foundation
• NU
  Newcastle University
• FP
  Fondation pour la Recherche Médicale
• VA
  Versus Arthritis
• NI
  National Institutes of Health

  Awards: AG58812, CA233790, AG26094, H2020
• DF
  Directorate for Biological Sciences
• H2
  Horizon 2020 Framework Programme

  Award: 857524
• MR
  Medical Research Council

  Award: MR/P020941/1
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/S006710/1, BB/S006710/1
• NI
  National Institute on Aging

  Awards: AG58812, AG26094