Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis

Abstract Background The triglyceride-glucose (TyG) index is a new alternative measure for insulin resistance. This meta-analysis was conducted to assess the associations of the TyG index with the risks of cardiovascular diseases and mortality in the general population. Methods The PubMed, Cochrane Library and Embase databases were searched for randomized controlled trials or observational cohort studies reporting associations of the TyG index with cardiovascular diseases and mortality from inception to April 16, 2022. Effect sizes were pooled using random-effects models. Robust error meta-regression methods were applied to fit nonlinear dose–response associations. Evidence quality levels and recommendations…

• NN
  National Natural Science Foundation of China

  Awards: 81760050, 81760048, 81760050, 82100347, 81760048, 82100273
• CP
  China Postdoctoral Science Foundation

  Awards: 2020M673016, 2021M703724
• NS
  Natural Science Foundation of Guangdong Province

  Award: 2022A1515010582
• NP
  National Postdoctoral Program for Innovative Talents

  Award: BX20200400