reviewCell Death and DiseaseJul 4, 2022GOLD OA

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

MKMeng KouLHLi HuangJYJinjuan YangZCZhixin ChiangSCShaoxiang Chen

Guangzhou Medical University · Universiti Tunku Abdul Rahman · +10 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of…

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Authors

16

Topics & keywords

Topics
Keywords
  • Mesenchymal stem cell
  • Paracrine signalling
  • Cell biology
  • Regeneration (biology)
  • Biology
  • Stem cell
  • Cell therapy
  • Regenerative medicine
UN Sustainable Development Goals
  • Good health and well-being
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