reviewFrontiers in Bioengineering and BiotechnologyJul 4, 2022GOLD OA

Advances in Hyaluronic Acid for Biomedical Applications

AYAqeela YasinYRYing RenJLJingan LiYSYulong ShengCCChang Cao

Zhengzhou University · Henan University of Technology · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Hyaluronic acid (HA) is a large non-sulfated glycosaminoglycan that is the main component of the extracellular matrix (ECM). Because of its strong and diversified functions applied in broad fields, HA has been widely studied and reported previously. The molecular properties of HA and its derivatives, including a wide range of molecular weights but distinct effects on cells, moisture retention and anti-aging, and CD44 targeting, promised its role as a popular participant in tissue engineering, wound healing, cancer treatment, ophthalmology, and cosmetics. In recent years, HA and its derivatives have played an increasingly important role in the aforementioned biomedical fields in the formulation of coatings,…

Citation impact

241
total citations
FWCI
15.76
Percentile
100%
References
90
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Hyaluronic acid
  • Self-healing hydrogels
  • CD44
  • Extracellular matrix
  • Nanotechnology
  • Glycosaminoglycan
  • Tissue engineering
  • Chemistry
UN Sustainable Development Goals
  • Good health and well-being
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