Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration
Fuzhou University · Sir Run Run Shaw Hospital · +4 more institutions
Abstract
Abstract Engineering a proper immune response following biomaterial implantation is essential to bone tissue regeneration. Herein, a biomimetically hierarchical scaffold composed of deferoxamine@poly(ε‐caprolactone) nanoparticles (DFO@PCL NPs), manganese carbonyl (MnCO) nanosheets, gelatin methacryloyl hydrogel, and a polylactide/hydroxyapatite (HA) matrix is fabricated to augment bone repair by facilitating the balance of the immune system and bone metabolism. First, a 3D printed stiff scaffold with a well‐organized gradient structure mimics the cortical and cancellous bone tissues; meanwhile, an inside infusion of a soft hydrogel further endows the scaffold with characteristics of the extracellular matrix. A…
Citation impact
- FWCI
- 26.31
- Percentile
- 100%
- References
- 71
Authors
11Topics & keywords
- Scaffold
- Materials science
- Bone healing
- Regeneration (biology)
- Angiogenesis
- Cell biology
- Bone tissue
- Extracellular matrix