Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological processes, including pathogenic microbe infection, metabolic adaptation, cancer, acute and chronic diseases, and other stress responses. The mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during hypoxia. Hypoxia-inducible factors (HIFs) sense hypoxia to regulate the expressions of a series of downstream genes expression, which participate in multiple processes including cell metabolism, cell growth/death, cell proliferation, glycolysis, immune response,…

• NN
  National Natural Science Foundation of China

  Awards: 81730061, 32100738, 32070148
• CP
  China Postdoctoral Science Foundation

  Award: 2021M691246