Liquid–liquid phase separation in tumor biology
Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +1 more institution
Abstract
Abstract Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids into micron-scale, liquid-like, membraneless bodies with specific functions, which were recently termed biomolecular condensates. Biomolecular condensates are executors underlying the intracellular spatiotemporal coordination of various biological activities, including chromatin organization, genomic stability, DNA damage response and repair, transcription, and signal transduction. Dysregulation of these cellular processes is a key event in the initiation and/or evolution of cancer, and emerging evidence has linked the…
Citation impact
- FWCI
- 19.49
- Percentile
- 100%
- References
- 387
Authors
7- XTXuhui TongCorresponding
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- RTRong Tang
Fudan University Shanghai Cancer Center, Shanghai Cancer Institute
- JXJin Xu
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- WWWei Wang
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- YZYingjun Zhao
Shanghai Medical College of Fudan University
Topics & keywords
- Biology
- Carcinogenesis
- Computational biology
- Function (biology)
- Systems biology
- Intrinsically disordered proteins
- Chromatin
- Cell biology
- Good health and well-being