SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

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doi:10.1038/s41564-022-01143-7

articleNature MicrobiologyJul 7, 2022HYBRID OA

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

BJBrian J. Willett JGJoe Grove OAOscar A. MacLean CWCraig Wilkie GDGiuditta De Lorenzo

MRC University of Glasgow Centre for Virus Research · University of Glasgow · +100 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1…

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Topics & keywords

Topics

Keywords

Endosome
Biology
Antigenicity
Virology
In vitro
Neutralization
Lipid bilayer fusion
Viral entry

UN Sustainable Development Goals

Good health and well-being

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