Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
Dalian Institute of Chemical Physics · Xiamen University · +8 more institutions
Abstract
Abstract Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N 4 site was synthesized for effective sepsis treatment. The de novo‐designed…
Citation impact
- FWCI
- 21.10
- Percentile
- 100%
- References
- 65
Authors
11- JYJi Yang
Dalian Institute of Chemical Physics, Xiamen University, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Collaborative Innovation Center of Chemistry for Energy Materials
- RZRuofei Zhang
Chinese Academy of Sciences, Institute of Biophysics
- HZHanqing Zhao
Chinese Academy of Sciences, Institute of Biophysics, University of Chinese Academy of Sciences
- HQHaifeng Qi
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Collaborative Innovation Center of Chemistry for Energy Materials
- JLJingyun Li
Chinese Academy of Sciences, Institute of Biophysics, Collaborative Innovation Center of Chemistry for Energy Materials
Topics & keywords
- Sepsis
- Oxidative stress
- Antioxidant
- Superoxide dismutase
- Reactive oxygen species
- Inflammation
- Inflammatory response
- Chemistry
Funding
- NNNational Natural Science Foundation of ChinaAwards: 22132006, 82122037, 31900981
- CAChinese Academy of SciencesAwards: JCTD-2020-08, 2019093
- CPChina Postdoctoral Science FoundationAward: 2021M703420
- YIYouth Innovation Promotion Association of the Chinese Academy of SciencesAwards: 2019093, JCTD-2020-08
- PUPeking University
- NKNational Key Research and Development Program of ChinaAwards: 2021M703420, 2021YFC2102900
- YIYouth Innovation Promotion AssociationAward: 2019093
- IOInstitute of Biophysics, Chinese Academy of Sciences