Neutrophil extracellular traps mediate m 6 A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells

Zhang, Hao; Liu, Jinlong; Zhou, Yilu; Qu, Mengdi; Wang, Yanghanzhao; Guo, Kefang; Shen, Ruling; Sun, Zhirong; Cata, Juan P.; Yang, Shuofei; Chen, Wankun; Miao, Changhong

doi:10.7150/ijbs.69141

articleInternational Journal of Biological SciencesJan 1, 2022GOLD OA

Neutrophil extracellular traps mediate m 6 A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells

HZHao Zhang JLJinlong Liu YZYilu Zhou MQMengdi Qu YWYanghanzhao Wang

Fudan University · Zhongshan Hospital · +3 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

, we elucidated and confirmed the critical role of ferroptosis in NETs-induced ALI. These findings support a role for NETs-induced METTL3 modification and the subsequent induction of ferroptosis in the pathogenesis of sepsis-associated ALI.

Citation impact

319

total citations

FWCI: 25.64
Percentile: 100%
References: 70

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Authors

12

Topics & keywords

Topics

Keywords

Neutrophil extracellular traps
Sepsis
Pathogenesis
Extracellular
Lung
Downregulation and upregulation
In vitro
Immunology

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