Pyroptosis in inflammatory diseases and cancer

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell contents. In normal physiology, pyroptosis plays a critical role in host defense against pathogen infection. However, excessive pyroptosis may cause immoderate and continuous inflammatory responses that involves in the occurrence of inflammatory diseases. Attractively, as immunogenic cell death, pyroptosis can serve as a new strategy for cancer elimination by inducing pyroptotic cell death and activating intensely antitumor immunity. To make good use of this…

• NN
  National Natural Science Foundation of China

  Awards: 2017YFC1309100, 21804104, 81671753, 91959124, 2017YFA0205200, 32071406, 32101147
• NS
  Natural Science Foundation of Shaanxi Province

  Awards: 2020PT-020, 2021JM-147
• NK
  National Key Research and Development Program of China

  Awards: 2017YFA0205200, 2017YFC1309100
• FR
  Fundamental Research Funds for the Central Universities

  Awards: JB211202, JB211204, JB211201
• NS
  Natural Science Basic Research Program of Shaanxi Province

  Award: 2021JM