articleNature CommunicationsJul 14, 2022GOLD OA

Microglia coordinate cellular interactions during spinal cord repair in mice

FHFaith H. BrennanYLYang LiCWCankun WangAMAnjun MaQGQi Guo

The Ohio State University Wexner Medical Center · Boston Children's Hospital · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated microglia and MDMs are morphologically identical and express similar phenotypic markers in vivo, identifying injury responses specifically coordinated by microglia has historically been challenging. Here, we pharmacologically depleted microglia and use anatomical, histopathological, tract tracing, bulk and single cell RNA sequencing to reveal the cellular and molecular responses to SCI controlled by microglia. We show that microglia are vital for SCI recovery and coordinate injury responses in CNS-resident glia and infiltrating leukocytes.…

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281
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Authors

18

Topics & keywords

Topics
Keywords
  • Microglia
  • Neuroscience
  • Spinal cord injury
  • Spinal cord
  • Biology
  • CX3CR1
  • Cell biology
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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